Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk. DHA is a component of lipid membranes and the myelin sheath. Wu, W. H., Lu, S. C., Wang, T. F., Jou, H. J., and Wang, T. A. 2016;104(4):1075-1082. View abstract. Am J Clin Nutr 2000;71:1462-9. View abstract. Effect of docosahexaenoic acid administration on plasma lipid profile and metabolic parameters of children with methylmalonic acidaemia. Br J Nutr 2008;99(2):421-431. View abstract. Vakhapova V, Cohen T, Richter Y, Herzog Y, Korczyn AD. Invest Ophthalmol Vis.Sci 2009;50(8):3613-3620. Mulder KA, King DJ, Innis SM. An eye disease that leads to vision loss in older adults (age-related macular degeneration or AMD). Smithers, L. G., Collins, C. T., Simmonds, L. A., Gibson, R. A., McPhee, A., and Makrides, M. Feeding preterm infants milk with a higher dose of docosahexaenoic acid than that used in current practice does not influence language or behavior in early childhood: a follow-up study of a randomized controlled trial. Prostaglandins Leukot.Essent.Fatty Acids 2007;77(5-6):295-300. Hamazaki, T., Sawazaki, S., Asaoka, E., Itomura, M., Mizushima, Y., Yazawa, K., Kuwamori, T., and Kobayashi, M. Docosahexaenoic acid-rich fish oil does not affect serum lipid concentrations of normolipidemic young adults. Bipolar disorder. Lauritzen, L., Jorgensen, M. H., Olsen, S. F., Straarup, E. M., and Michaelsen, K. F. Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants. View abstract. Ref. View abstract. Re-narrowing of a blood vessel after stent placement or angioplasty (restenosis). Thies F, Nebe-von-Caron G, Powell JR, et al. Lipids 1999;34(8):793-799. Am J Clin Nutr. View abstract. View abstract. View abstract. Conquer, J. FDA announces qualified health claims for omega-3 fatty acids. Invest Ophthalmol Vis.Sci 1992;33(11):3242-3253. Carlson, S. E., Ford, A. J., Werkman, S. H., Peeples, J. M., and Koo, W. W. Visual acuity and fatty acid status of term infants fed human milk and formulas with and without docosahexaenoate and arachidonate from egg yolk lecithin. Food Chem Toxicol. Agostoni, C., Harvie, A., McCulloch, D. L., Demellweek, C., Cockburn, F., Giovannini, M., Murray, G., Harkness, R. A., and Riva, E. A randomized trial of long-chain polyunsaturated fatty acid supplementation in infants with phenylketonuria. Prenatal exposure to methyl mercury from fish consumption and polyunsaturated fatty acids: associations with child development at 20 mo of age in an observational study in the Republic of Seychelles. Usually, government's categorizes medicines that can be addictive as controlled substances. View abstract. J Nutr 2009;139(5):861-868. Arch Ophthalmol 2008;126(9):1274-1279. (check all that apply). In case you miss a dose, use it as soon as you notice. Do not use extra dose to make up for a missed dose. Benton D, Donohoe RT, Clayton DE, Long SJ. Research on the effects of DHA in people with retinitis pigmentosa is inconsistent. Arch.Ophthalmol. N Engl J Med. View abstract. 2017 Mar 30;376(13):1245-1255. doi: 10.1056/NEJMoa1611942. Br J Nutr 2010;103(2):235-242. View abstract. View abstract. The role of essential fatty acids in development. View abstract. Docosahexaenoic acid (DHA) is essential for the growth and functional development of the brain in infants. J Nutr Sci Vitaminol. B., Saugstad, O. D., Smith, L., Saarem, K., Solvoll, K., Ganes, T., and Drevon, C. A. J Med Food. View abstract. 2010 Nov;6(6):456-64. View abstract. Drover JR, Felius J, Hoffman DR, Castañeda YS, Garfield S, Wheaton DH, Birch EE. The omega-3 (or ω-3) designation means that there is a double bond at the third carbon atom from the far end of the hydrocarbon chain. Smithers, L. G., Gibson, R. A., McPhee, A., and Makrides, M. Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial. Am J Clin Nutr 2000;71:323S-6S. Nutrition 2006;22(7-8):731-737. 2014 Sep;158(1-3):230-5. Circulation 9-12-2000;102(11):1264-1269. Mini.Rev Med Chem 2004;4(8):859-871. Am.J.Clin.Nutr. View abstract. Hamazaki T, Sawazaki S, Itomura M, et al. View abstract. View abstract. Aggressive prostate cancer: high blood levels of omega-3s doubled the risk, but high levels of trans-fatty acids cut risk in half. Cancer. Reprod.Nutr Dev. Supplementation with docosahexaenoic acid in the last trimester of pregnancy: maternal-fetal biochemical findings. Lipids 1989;24(12):998-1003. Pediatr Res 2005;58:235-42. Alicandro G, Faelli N, Gagliardini R, Santini B, Magazzù G, Biffi A, Risé P, Galli C, Tirelli AS, Loi S, Valmarana L, Cirilli N, Palmas T, Vieni G, Bianchi ML, Agostoni C, Colombo C. A randomized placebo-controlled study on high-dose oral algal docosahexaenoic acid supplementation in children with cystic fibrosis.Prostaglandins Leukot Essent Fatty Acids. Birch, E. E., Hoffman, D. R., Uauy, R., Birch, D. G., and Prestidge, C. Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. Am J Clin Nutr 2008;87(5):1521-1529. Vision problems in people with diabetes (diabetic retinopathy). View abstract. 2019;2(2):e190088. Hayashi, H., Tanaka, Y., Hibino, H., Umeda, Y., Kawamitsu, H., Fujimoto, H., and Amakawa, T. Beneficial effect of salmon roe phosphatidylcholine in chronic liver disease. View abstract. Makrides, M., Gibson, R. A., McPhee, A. J., Collins, C. T., Davis, P. G., Doyle, L. W., Simmer, K., Colditz, P. B., Morris, S., Smithers, L. G., Willson, K., and Ryan, P. Neurodevelopmental outcomes of preterm infants fed high-dose docosahexaenoic acid: a randomized controlled trial. J Nutr 2008;138(12):2510-2514. Higher blood levels of DHA are linked with a reduced risk of stroke. Terano, T., Fujishiro, S., Ban, T., Yamamoto, K., Tanaka, T., Noguchi, Y., Tamura, Y., Yazawa, K., and Hirayama, T. Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases. 2013 Apr;97(4):808-15. View abstract. View abstract. Birch EE, Garfield S, Hoffman DR, et al. Crit Rev Food Sci Nutr. View abstract. Br J Nutr 2006;95(3):525-531. Grynberg, A. Please consult your physician or pharmacist or refer to product package. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Early research suggests that feeding infants formula with added DHA and the fatty acid arachidonic acid does not seem to prevent the development of ear infections compared to feeding regular formula. Stark, K. D. and Holub, B. J. Stough C, Downey L, Silber B, Lloyd J, Kure C, Wesnes K, Camfield D. The effects of 90-day supplementation with the omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population. Research also shows that when a pregnant mother takes DHA, it might lower the child's blood pressure if he/she becomes overweight or obese by the age of 5. A randomized controlled trial to prevent post-operative atrial fibrillation by antioxidant reinforcement. View abstract. Eur J Clin Nutr 2004;58:838. Cancer . View abstract. Some early research shows that giving full-term infants formula with added DHA and the fatty acid arachidonic acid reduces the risk of lower airway infections such as bronchitis and whooping cough. DHA also serves as a precursor for signaling molecules such as prostaglandins and eicosanoids. Potential role of dietary n-3 fatty acids in the prevention of dementia and macular degeneration. View abstract. Am J Clin Nutr 2003;78:65-71.. View abstract. A. Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. View abstract. 2006;63(11):1545-1550. A., Alpert, J. E., and Fava, M. A double-blind dose-finding pilot study of docosahexaenoic acid (DHA) for major depressive disorder. Maternal docosahexaenoic acid supplementation and fetal accretion. Woodman RJ, Mori TA, Burke V, et al. View abstract. Semin.Reprod.Endocrinol 1998;16(4):235-239. A randomized trial of DHA intake during infancy: school readiness and receptive vocabulary at 2-3.5 years of age. 73310-11-9. View abstract. Diarrhea. A motor skill disorder marked by clumsiness (developmental coordination disorder or DCD). Am J Clin Nutr 2001;73:209-18.. View abstract. Docosahexaenoic Acid - Uses, Side-effects, Reviews, and Precautions - TabletWise. Montgomery P, Spreckelsen TF, Burton A, Burton JR, Richardson AJ. Taking DHA during pregnancy does not seem to significantly improve infant or child development. Voigt RG, Llorente AM, Jensen CL, et al. 2013 Oct;44(10):2710-7. O'Shea, K. M., Khairallah, R. J., Sparagna, G. C., Xu, W., Hecker, P. A., Robillard-Frayne, I., Des, Rosiers C., Kristian, T., Murphy, R. C., Fiskum, G., and Stanley, W. C. Dietary omega-3 fatty acids alter cardiac mitochondrial phospholipid composition and delay Ca2+-induced permeability transition. Am J Clin Nutr 2008;88(4):1049-1056. Docosahexaenoic acid ethyl ester. Eur J Pediatr 2000;159(1-2):49-53. Makrides, M., Gibson, R. A., McPhee, A. J., Yelland, L., Quinlivan, J., and Ryan, P. Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial. View abstract. Decline in memory and thinking skills in older people that is more than what is normal for their age. Ryan, A. S. and Nelson, E. B. Assessing the effect of docosahexaenoic acid on cognitive functions in healthy, preschool children: a randomized, placebo-controlled, double-blind study. 1993;33(4 Pt 1):425-427. View abstract. Am J Clin Nutr 2011;93(6):1293-1299. Don't confuse DHA with EPA ( eicosapentaenoic acid ). Type 2 diabetes. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Fekete, K., Marosvolgyi, T., Jakobik, V., and Decsi, T. Methods of assessment of n-3 long-chain polyunsaturated fatty acid status in humans: a systematic review. View abstract. Am.J.Obstet.Gynecol. J Nutr 2003;133:2210-3.. View abstract. View abstract. DHA is metabolically related to other n-3 fatty acids: it can be synthesised from the plant essential fatty acid α-linolenic acid (ALA). Docosahexaenoic Acid. A critical appraisal of the role of dietary long-chain polyunsaturated fatty acids on neural indices of term infants: a randomized, controlled trial. Neff, L. M., Culiner, J., Cunningham-Rundles, S., Seidman, C., Meehan, D., Maturi, J., Wittkowski, K. M., Levine, B., and Breslow, J. L. Algal docosahexaenoic acid affects plasma lipoprotein particle size distribution in overweight and obese adults. J Nutr. Trademarks & Tradenames used herein are the property of their respective holders. Clin Nutr 2009;28(1):71-77. Rix TA, Joensen AM, Riahi S, Lundbye-Christensen S, Overvad K, Schmidt EB. Aldamiz-Echevarria, L., Sanjurjo, P., Elorz, J., Prieto, J. A docosahexaenoic acid-functional food during pregnancy benefits infant visual acuity at four but not six months of age. 4-15-2000;98(2):123-132. 2014 Oct 1;76(7):559-66. CONDITIONS OF USE AND IMPORTANT INFORMATION: View abstract. Mori, T. A., Watts, G. F., Burke, V., Hilme, E., Puddey, I. View abstract. 2003;57(6):727-734. Lancet 1999;353:812-3. Am J Cardiol 4-1-2005;95(7):869-871. 2013 Jan 14;109(1):155-61. The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. View abstract. Stonehouse W, Conlon CA, Podd J, Hill SR, Minihane AM, Haskell C, Kennedy D. DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial. 2014 Jan;34(1):17-24. 2013 Feb;88(2):163-9. view abstract. Lucas A, Stafford M, Morley R, et al. Cancer Lett 2001;163:171-8. View abstract. View abstract. 2014 May;65(3):375-9. View abstract. 1998;44(2):201-209. Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial. View abstract. View abstract. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. Docosahexaenoic acid definition is - an omega-3 fatty acid C22H32O2 found especially in fish of cold waters —abbreviation DHA. View abstract. Manes M, Alberici A, Di Gregorio E, Boccone L, Premi E, Mitro N, et al. Growth to age 18 months following prenatal supplementation with docosahexaenoic acid differs by maternal gravidity in Mexico. Drugs in Pregnancy and Lactation 2012;25(4);3-4. Theobald, H. E., Goodall, A. H., Sattar, N., Talbot, D. C., Chowienczyk, P. J., and Sanders, T. A. Low-dose docosahexaenoic acid lowers diastolic blood pressure in middle-aged men and women. Lipids 1999;34 Suppl:S345-S346. Prisco D, Paniccia R, Bandinelli B, et al. Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension. Pastor, N., Soler, B., Mitmesser, S. H., Ferguson, P., and Lifschitz, C. Infants fed docosahexaenoic acid- and arachidonic acid-supplemented formula have decreased incidence of bronchiolitis/bronchitis the first year of life. Docosahexaenoic acid, but not eicosapentaenoic acid, improves septic shock-induced arterial dysfunction in rats. J Pediatr Gastroenterol Nutr. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Nutr Res. Effects of lutein and docosahexaenoic Acid supplementation on macular pigment optical density in a randomized controlled trial. Eur J Clin Nutr 2006;60(3):386-392. Docosahexaenoic acid (DHA) is a member of a group of natural compounds known to many as omega-3 fatty acids. Safety assessment of DHA-rich microalgae from Schizochytrium sp. Br J Nutr. View abstract. Sawazaki, S., Hamazaki, T., Yazawa, K., and Kobayashi, M. The effect of docosahexaenoic acid on plasma catecholamine concentrations and glucose tolerance during long-lasting psychological stress: a double-blind placebo-controlled study. Biotin in human nutrition. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the trials of hypertension prevention. What precautions should you take while using Docosahexaenoic Acid? View abstract. View abstract. Agostoni, C., Zuccotti, G. V., Radaelli, G., Besana, R., Podesta, A., Sterpa, A., Rottoli, A., Riva, E., and Giovannini, M. Docosahexaenoic acid supplementation and time at achievement of gross motor milestones in healthy infants: a randomized, prospective, double-blind, placebo-controlled trial. Lafuente M, Ortín L, Argente M, Guindo JL, López-Bernal MD, López-Román FJ, et al. Ann Neurol. Medications for high blood pressure (Antihypertensive drugs) interacts with DOCOSAHEXAENOIC ACID (DHA). 2019 Jul;144(1). View abstract. Prev Cardiol 2003;6:136-46. Formula supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA): a critical review of the research. The effect of taking DHA alone is unknown. Michael-Titus, A. T. Omega-3 fatty acids and neurological injury. Yagi S, Kondo D, Ise T, et al. Gould JF, Treyvaud K, Yelland LN, et al. Young, G. S., Maharaj, N. J., and Conquer, J. Maternal fish oil supplementation in lactation and growth during the first 2.5 years of life. Effects of docosahexaenoic acid supplementation on blood lipids, estrogen metabolism, and in vivo oxidative stress in postmenopausal vegetarian women. Lee, J. Y., Plakidas, A., Lee, W. H., Heikkinen, A., Chanmugam, P., Bray, G., and Hwang, D. H. Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. Yaemsiri S, Sen S, Tinker LF, Robinson WR, Evans RW, Rosamond W, Wasserthiel-Smoller S, He K. Serum fatty acids and incidence of ischemic stroke among postmenopausal women. Hypertension prevention: from nutrients to (fortified) foods to dietary patterns. DHA can decrease blood pressure. Some research suggests that infants who do not receive DHA from breast milk or formula have delayed mental and visual development compared to those who receive enough DHA. Ann Nutr Metab. Lipids 2007;42(11):1011-1024. View abstract. View abstract. Hoffman, D. R., Locke, K. G., Wheaton, D. H., Fish, G. E., Spencer, R., and Birch, D. G. A randomized, placebo-controlled clinical trial of docosahexaenoic acid supplementation for X-linked retinitis pigmentosa. Johnson, E. J., Chung, H. Y., Caldarella, S. M., and Snodderly, D. M. The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation. Am J Clin Nutr 1995;62:761-8. The Mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trial. Also, levels of DHA in the blood of the pregnant mother do not appear to be associated with risk of type 1 diabetes in the child. Am J Clin Nutr 2004;80(1):45-50. Some researchers think that taking DHA after starting a statin might help prevent restenosis in people who just had a stent placed. Early Hum Dev. J Am Coll Cardiol. View abstract. Early research suggests that taking DHA for up to one year does not improve lung function in people with cystic fibrosis. View abstract. Johnson, E. J., McDonald, K., Caldarella, S. M., Chung, H. Y., Troen, A. M., and Snodderly, D. M. Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. Am.J.Clin.Nutr. Judge, M. P., Harel, O., and Lammi-Keefe, C. J. View abstract. Docosahexaenoic acid-mediated protein aggregates may reduce proteasome activity and delay myotube degradation during muscle atrophy in vitro. View abstract. J Clin Psychiatry. View abstract. View abstract. Scand J Gastroenterol Suppl 1988;143:135-141. Research suggests that taking DHA does not improve mental performance in healthy children, young women, or healthy adults. Taking DHA by mouth does not seem to relieve or prevent depression symptoms in most people. Taking DHA by mouth together with evening primrose oil, thyme oil, and vitamin E seems to improve movement in children with this condition. Heart. De, Caterina R., Liao, J. K., and Libby, P. Fatty acid modulation of endothelial activation. 2004;93(6):734-738. 2003;73(5):357-368. Voigt RG, Mellon MW, Katusic SK, Weaver AL, Matern D, Mellon B, Jensen CL, Barbaresi WJ. J Nutr Biochem 2010;21(5):444-450. 2014;14:168. View abstract. Arterburn, L. M., Oken, H. A., Bailey, Hall E., Hamersley, J., Kuratko, C. N., and Hoffman, J. P. Algal-oil capsules and cooked salmon: nutritionally equivalent sources of docosahexaenoic acid. View abstract. View abstract. Lancet 1999;354:1948-54. J Cyst.Fibros. Decline in memory and thinking skills that occurs normally with age. J.Nutr. 2013 Oct 15;62(16):1457-65. CCRIS 7132. You must supplicate this deficit in food or supplements. Retina 2005;25(8 Suppl):S52-S54. View abstract. Mullen, A., Loscher, C. E., and Roche, H. M. Anti-inflammatory effects of EPA and DHA are dependent upon time and dose-response elements associated with LPS stimulation in THP-1-derived macrophages. Conquer JA, Holub BJ. Park, Y., Jones, P. G., and Harris, W. S. Triacylglycerol-rich lipoprotein margination: a potential surrogate for whole-body lipoprotein lipase activity and effects of eicosapentaenoic and docosahexaenoic acids. Verduci E, Agostoni C, Radaelli G, Banderali G, Riva E, Giovannini M. Blood lipids profile in hyperlipidemic children undergoing different dietary long chain polyunsaturated supplementations: a preliminary clinical trial. Beyond the Mediterranean diet: the role of omega-3 Fatty acids in the prevention of coronary heart disease. DHA is thought to be an essential nutrient required throughout the life cycle for the maintenance of … But taking DHA during chemotherapy treatment might help delay progression of the breast cancer and improve survival. Blood phospholipid fatty acid analysis of adults with and without attention deficit/hyperactivity disorder. View abstract. Quinn, J. F., Raman, R., Thomas, R. G., Yurko-Mauro, K., Nelson, E. B., Van, Dyck C., Galvin, J. E., Emond, J., Jack, C. R., Jr., Weiner, M., Shinto, L., and Aisen, P. S. Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial. Mori TA, Burke V, Puddey IB, et al. View abstract. Mukherjee, P. K., Chawla, A., Loayza, M. S., and Bazan, N. G. Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease. Smithers, L. G., Gibson, R. A., and Makrides, M. Maternal supplementation with docosahexaenoic acid during pregnancy does not affect early visual development in the infant: a randomized controlled trial. Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. View abstract. View abstract. Decsi, T., Campoy, C., and Koletzko, B. Food Nutr Bull 2010;31(2 Suppl):S108-S116. Morris MC, Evans DA, Bienias JL, et al. Innis, S. M., Gilley, J., and Werker, J. 2013 Feb 15;5(2):543-51. Retrieved June 11, 2020, from, "Docosahexaenoic Acid - Uses, Side-effects, Reviews, and Precautions - TabletWise". Egert, S., Kannenberg, F., Somoza, V., Erbersdobler, H. F., and Wahrburg, U. Dietary alpha-linolenic acid, EPA, and DHA have differential effects on LDL fatty acid composition but similar effects on serum lipid profiles in normolipidemic humans. View abstract. 2014 Jan 10;9(1):e83764. Chan SS, Luben R, Olsen A, Tjonneland A, Kaaks R, Lindgren S, Grip O, Bergmann MM, Boeing H, Hallmans G, Karling P, Overvad K, Venø SK, van Schaik F, Bueno-de-Mesquita B, Oldenburg B, Khaw KT, Riboli E, Hart AR. Seven-Year Follow-up of Children Born to Women in a Randomized Trial of Prenatal DHA Supplementation. Koletzko, B., Larque, E., and Demmelmair, H. Placental transfer of long-chain polyunsaturated fatty acids (LC-PUFA). Early research also shows that taking DHA for one year improves symptoms of dementia caused by a condition related to blood clots in the brain (thrombotic cerebrovascular diseases). View abstract. 2012 Apr;32(2):200-6. 49(1), e287 (2017). Dietary docosahexaenoic acid supplementation in children with autism. Clandinin, M. T., Van Aerde, J. E., Merkel, K. L., Harris, C. L., Springer, M. A., Hansen, J. W., and Diersen-Schade, D. A. Psychiatry 2-1-2009 ; 33 ( 11 ):1577-1585 Meyer BJ gives it unique physical and functional of. Mitmesser, S. A., woodman, R. 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